Note: this deletes any information not yet synced with the server

Outlook for Windows

1. Exit Outlook and Skype for Business.
2. From the Start menu, choose Run.
3. In the Run window, type this path in the Open box  "%LOCALAPPDATA%\Microsoft\Outlook\"
4. Click OK
5. Find the .ost file and rename or delete it (you may need to Show Hidden Files and Show Extensions to see the file)
6. Remove the following files:  any .xml files, any .nst files
7. Open the RoamCache folder and delete all items
8. Open the HubAppFileCache folder and delete all items
9. Open the Offline Address Books folder and delete all items
10. Open the 16 folder and delete all items
11. Restart Outlook

Outlook for Mac (New) 

1. Choose Tools > Accounts.
2. In the left pane, select the account you want to reset.
3. On the bottom left, click the gear icon and select Reset Account from the list.

Outlook for Mac (Legacy) 

1. In the navigation pane, Ctrl+click or right-click the Exchange folder for which you want to empty the cache, and then click Properties.
2. On the General tab, click Empty Cache. After the folder is empty, Outlook automatically downloads the items from the Exchange server.